, Nguyen SC The Physician Global Assessment (PGA) has been shown to be a valid, responsive, and feasible instrument to capture disease activity in systemic lupus erythematosus (SLE), but its low reliability further supports the need for a standardisation of its scoring. Laboratory Investigation Results Influence Physician's Global Feasibility is the ease of application of the instrument of measure in its intended setting [106]. Rheumatology (Oxford). Criterion validity. In one open-label study [43], the decrease in PGA score was considered the primary endpoint. Complement-Targeted Therapeutics Market Report (2022 to , Ding HH Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. , Saad-Magalhes C Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring. The Physician Global Assessment (PGA) is an important tool for assessing disease activity in lupus. Montreal, Canada Area. , Petri MA A good responsiveness for PGA was shown in eight studies. Kiani AN , Allen E The literature search identified 91 studies. MeSH At a glance: Common scores used in rheumatology Faculty Publications: Feb. 23-March 2 Annapureddy N Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. New Tools to Measure Disease Activity in SLE - Rheumatology Network 2014 - 20184 years. Methods , Schur PH. All rights reserved. A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. , Beaumont JL SFI, LLDAS, SRI, Definitions of Remission in Systemic Lupus Erythematosus remission criteria) [3, 5, 10, 1315, 104]. Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. The site is secure. (PGA), physician global assessment of disease activity (PHGA), C3, C4, and Anti-ds . PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. . BILAGAB . , Patrick DL Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. , Askanase A Before et al. , Guzmn RM The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Physician global assessment in systemic lupus erythematosus: can we , Devilliers H , Chatzidionysiou K A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [17], searching for articles reporting on the use of PGA in SLE. Mok CC Liang MH BICLA responders had fewer lupus-related serious . They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. The intrarater reliability (intraRR) is the ability to provide consistent scores in a stable population by the same assessor over time. , Urowitz MB et al. , Smiley A. Askanase AD , Gladman DD , Sengupta M We have systematically reviewed all studies about validation of the PGA in SLE. Unauthorized use of these marks is strictly prohibited. et al. Fanouriakis A Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . In support of its face validity, the PGA was used to define the disease activity score in all 91 studies retrieved by the literature search, having a role as an outcome measure as well as a comparator to assess the validity of other indices. Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. AU - Kandane-Rathnayake, Rangi. It operates in Albuquerque, and New Mexico. , Arbab-Zadeh A Quimby KR Touma Z The OMERACT defines an instrument as an outcome measure if it passes the three pillars of evidence: truth (that refers to validity), discrimination (that includes reliability and responsiveness) and feasibility. et al. BATCH RUBY INTENSIVE REVIEWRTRMF 3. Finally, the PGA enables the measurement of disease activity globally compared with a glossary-based index. HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. Accessibility Global Automatic Chemiluminescence Immunoassay Analyzer Market 2023 Beaton DE Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. , Sjwall C. Strand V , Socher SA Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. Results. ECG - correct answer no sleep the night before, meals allowed, no stimulants/tranquilizers for 24-48 hours before. Few studies reported on whether serological activity should be incorporated in the PGA. This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . Dynabook PX1900E-1NCA, PROTECTIVE SLE (PX1900E-1NCA) et al. 04 Measuring SLE disease activity in 2020: perspectives from clinical A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. Thanou A The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Akhter E Epub 2014 Jul 10. , Perneger T , Mohan C. Giangreco D The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. Frontiers | Cutaneous lupus erythematosus disease assessment , Jolly M. Mok CC , Su J All rights reserved. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. How does one assess and monitor patients with systemic lupus , Bentow C Use of Physician Global Assessment in systemic lupus erythematosus: a Published by Oxford University Press on behalf of the British Society for Rheumatology. et al. , Mazur M. Fatemi A Conducting medical monitoring, safety review, narrative writing and etc.. Perform medical assessment of individual . , Pego-Reigosa J-M AU - Kasitanon, Nuntana. Your recommendations as to what might or should be done in relation to various issues observed. PDF Physician s global assessment is often useful in SLE, but not always Gordon C , Taghavi-Zadeh S The index assesses separately eight organ-based systems. Patient global assessment in measuring disease activity in rheumatoid Aranow C The index has proved quick and easy to use despite a comprehensive database and compares favourably with . 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 , Tugwell P PGA is an important tool for assessing disease activity, response to treatment (it is a component . Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. In the second column, the definitions were reported according to the VAS used in the study. Careers. Touma Z In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. Schneider M , Suriano A Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. , Francis S The PGA is a valid instrument but has variable reliability; its scoring should be standardized. How should lupus flares be measured? , ODell JR , Socher SA , Sjwall C Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). Reliability. Five centres in Great Britain and the Republic of Ireland have collaborated to produce a computerized index of clinical disease activity in systemic lupus erythematosus, based on the principle of the physician's intention to treat. , Chang AY inflammation (duration and severity of morning stiffness as measured by BASDAI). official website and that any information you provide is encrypted Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). et al. TOTAL DOCUMENTS. The PGA was introduced in 1998 by a US Food and Drug Administration panel as the preferred tool to assess and record the severity of disease in clinical studies, and typically rates a patient's disease from 'clear' to 'severe' or 'very severe' [1, 2]. Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26]. Eudy AM , Kraag GR It was published in 1977 and was initially designed for the measurement of self-assessed pain in rheumatoid arthritis although it has since been used to evaluate RA more globally. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. Despite the need for new treatments in CLE . Physician Global Assessment International Standardisation COnsensus in independently selected the articles, initially on the basis of titles and abstracts, then, if necessary, on the full texts, an eligibility assessment was performed independently in a blinded standardized manner. , Wetter J , Ibanez D Strength. PDF Getting To Know Dr. Derek Shendell, New Safe Schools Project Director [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. Medical Cannabis Use by Rheumatology Patients Following Recreational Scoring systemic lupus erythematosus (SLE) disease activity with simple 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; et al. , Raeisi A Please enable it to take advantage of the complete set of features! , Lau CS , Gayet-Ageron A , Urowitz MB The Physician Global Assessment (PGA) is a frequently used co-primary end point in psoriasis clinical trials. et al. doi: 10.1136/rmdopen-2022-002395. The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. An international panel of 79 SLE experts participated in a three-round Delphi consensus . In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. Of note, it is not trivial that we found a good convergent validity with other instruments (SLEDAI, BILAG, LAI, SLAM and ECLAM) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. . Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. , Brunetta P Barr et al. , Klein-Gitelman MS In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. AU - Louthrenoo, Worawit. , Birmingham DJ FOIA Data regarding divergent validity are lacking for the PGA. et al.